Scientists at the Xi’an Jiao Tong University have observed a new dark matter in the human genome-66814

Xi’an Jiao Tong University scientists observed the human genome new "dark matter" – Beijing, Beijing, October 9 Xi’an Xinhua (reporter Tian Jin) Xi’an Jiao Tong University said on 9, the school scientific research team through the development of new computer algorithms and analysis process, analyze and report all types of variation in 250 healthy families in the genome, a large number of the complex variation including never before observed, namely in the genome of "dark matter". According to reports, there is no two people have exactly the same genome sequence, even the genome of identical twins, in the development process of differentiation will appear on the genetic material acquired differences. Some differences give an individual a difference in height, while others may determine whether people are susceptible to certain diseases. 20 scientific research institutions of Xi’an Jiao Tong University and Professor Ye Kai team and Holland, the United States, Germany, through the development of new computer algorithms and analysis process, analyze and report all types of variation in 250 healthy families in the genome, a large number of complex type variation including never before observed, namely in the genome of "dark material". In the identification of the 1 million 900 thousand large genomic variants, including the deletion of large fragments of DNA, jump DNA or the emergence of a large fragment of DNA. These mutations also occur in important functional regions of the genome, such as coding regions of critical proteins, thereby causing damage to the function of the resulting proteins. Researchers, many of the major structural changes in the genome is often not in the coding part of the gene, some of the effects of variability is often difficult to predict. The researchers reported two interesting examples of the discovery of additional DNA fragments outside the protein coding region, and a significant regulatory effect on the expression of nearby genes. This suggests that genomic structural variation, even in the coding region, needs close monitoring. The study provides a complete set of genomic variants, providing the possibility of studying the effects of structural variation in large genomes. In addition, the study also reveals a large number of large fragments of DNA that have never been observed, and these "extra" DNA do indeed encode proteins. If the researchers found a new "ZNF" gene, half of Holland’s individuals had. The gene and other "dark matter" have been saved to the international database for scientists to learn more about human disease. (end)相关的主题文章: